Abstract – Platelet-rich plasma (PRP) and extracorporeal shockwave therapy (ESWT) are both used for the treatment of soft tissue injuries in horses. Clinically, the question has been raised whether these two therapies could be used in combination. The hypothesis of this study was the application of ESWT to PRP would increase the release of platelet derived growth factors (PDGF) and transforming growth factors beta 1 (TGFBeta) from platelets.
Shock Wave Studies
Many studies have been completed supporting the efficacy of extracorporeal shock wave therapy (ESWT) on horses.
Abstract – Muscle injuries are among the most common sports-related lesions in athletes; however, optimal treatment remains obscure. Extracorporeal shock wave therapy (ESWT) may be a promising approach in this context, because it has gained increasing importance in tissue regeneration in various medical fields.
Abstract – In vitro models of human tenocytes derived from healthy as well as from ruptured tendons were established, characterized and used at very early passage (P1) to evaluate the effects of Extracorporeal Shock Wave Treatment (ESWT). The molecular analysis of traditional tenocytic markers permitted us to detect in our samples the simultaneous expression of all these genes and allowed us to compare their levels of expression in relationship to the source of the cells and treatments.
Abstract – There is currently great interest in the use of Extracorporeal Shock Wave Therapy (ESWT) and in clarifying the mechanisms of action in tendon pathologies. The success rate ranges from 60% to 80% in epicondylitis, plantar fasciitis, cuff tendinitis, trocanteritis, Achilles tendinitis or jumper’s knee.
Abstract – The aim of this study was to investigate whether the effects of extracorporeal shock wave therapy (ESWT) could affect the behavior of primary cultured human tenocytes over a 12-day period. Conclusion: ESWT promoted cell growth and collagen synthesis of primary cultured human tenocytes. The clinical benefits of ESWT may be ascribed to an increased efficiency of tendon repair after injury.
Abstract – These studies were conducted to investigate the biological mechanism of musculoskeletal shockwaves. The investigations were independently performed in tendon and bone, and at the tendon-bone interface in rabbits.
Abstract – Little has been reported about the biologic effect of shock waves on human normal or pathologic tendon tissue. We hypothesized that inflammatory cytokine and MMP production would be down-regulated by shock wave stimulation.
Abstract – The shock wave is an effective noninvasive modality for resolving various tendon pathologies. However, scientific rationale in mechanism of shock wave therapy remains limited. This study aims to investigate the effects of shock waves and their biochemical mechanisms on tenocyte proliferation and collagen synthesis.
Abstract – Extracorporeal shock wave therapy (ESWT) is an effective method of decreasing clinical signs of lameness associated with osteoarthritis (OA). In this model, ESWT performed better than intra-muscular polysulfated glycosaminoglycans.
Abstract – Shock wave therapy is a relatively new modality for use in equine practice. The application of shock waves is dependent on an accurate diagnosis and localization of the lesion. At this time we are still gaining knowledge on proper application and what musculoskeletal problems will respond to treatment.
Abstract – Extracorporeal shock wave therapy was effective in decreasing the lameness associated with navicular syndrome in 81% of the horses as determined by an unmasked evaluator and in 58% of the horses with masked evaluators.
Abstract – Extracorporeal shock waves (ESW) have recently been used in resolving tendinitis. However, mechanisms by which ESW promote tendon repair is not fully understood. In this study, we reported that an optimal ESW treatment promoted healing of Achilles tendinitis by inducing TFG-Beta1 and IGF-I.